Revista Portuguesa de Medicina Geral e Familiar
ISSN 2182-5173
MOITA, Catarina Ferreira et al. Statin-associated necrotizing myopathy: a rare etiology. []. , 36, 6, pp.503-506. 01--2020. ISSN 2182-5173. https://doi.org/10.32385/rpmgf.v36i6.12629.
Introduction:
Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation.
Case description:
We report the case of a 72-year-old female with a 3-week-history of asthenia, increasing proximal tetraparesis, without pain, fever, or other symptoms, and elevated creatine kinase levels. Previous history was remarkable for dyslipidemia controlled with statin therapy. A muscular biopsy was performed, leading to the diagnosis of necrotizing myopathy. A body computed tomography (CT) scan was normal. Corticotherapy was initiated with progressive clinical and analytical improvement.
Discussion:
This case depicts an uncommon and underdiagnosed pathology which may be associated with statin treatment or cancer, that requires an early diagnosis and close follow-up for better clinical outcomes.
: Myositis; Rhabdomyolysis; Hydroxymethylglutaryl-CoA reductase inhibitors; Autoantibodies..