Abstract

PALHINHA, Ana; ROMEIRA, Ana Margarida  and  PINTO, Paula Leiria. Hypersensitivity to ophthalmic mydriatic agents: A case report. Rev Port Imunoalergologia [online]. 2021, vol.29, n.1, pp.55-59.  Epub Mar 31, 2021. ISSN 0871-9721.  https://doi.org/10.32932/rpia.2021.03.054.

The increasing use of ophthalmic medication has led to the emergence of a greater number of hypersensitivity reactions (HR) associated with it. These are mostly type IV HR and, rarely, immediate. The agents involved are diverse, from active substances such as mydriatic eye drops (CM) to inactive substances (preservatives). We report the case of a patient with suspected immediate and non‑immediate HR to ophthalmic medication (tropicamide 10mg/ml, phenylephrine 100mg/ml and cyclopentolate 10mg/ml), whose investigation included skin prick tests (SPT) and patch tests (PT) with the mentioned drugs. SPT were positive for cyclopentolate, with immediate reaction, and for phenylephrine at 48 and 96 hours. The PT were positive at 48 and 96 hours for phenylephrine. According to these results, we assumed allergy to phenylephrine and cyclopentolate and an ocular provocation test was performed with tropicamide which was tolerated by the patient.

Keywords : Mydriatic eye drops; contact dermatitis; ocular medication; hypersensitivity reactions..

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