Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Similars in SciELO
Share
Acta Portuguesa de Nutrição
On-line version ISSN 2183-5985
Abstract
MONTEIRO, Joana de Sousa and VAZ, Teresa Raquel. THE USE OF ALFA-LIPOIC ACID IN THE TREATMENT OF CARPAL TUNNEL SYNDROME: AN EVIDENCE-BASED REVIEW. Acta Port Nutr [online]. 2023, n.32, pp.54-58. Epub Oct 25, 2023. ISSN 2183-5985. https://doi.org/10.21011/apn.2023.3209.
INTRODUCTION:
Carpal Tunnel Syndrome is one of the most common neuropathies in adults and impacts on functionality and quality of life. The usual conservative treatment has a low level of evidence. Given its antioxidant effects, alpha-lipoic acid has been used to relieve symptoms and deficits of different neuropathies. In this way alpha-lipoic acid emerges as a potential symptomatic treatment in Carpal Tunnel Syndrome.
OBJECTIVES:
To evaluate the efficacy of alpha-lipoic acid in symptomatic treatment of carpal tunnel syndrome in adults. METHODOLOGY: Search for meta-analyses, systematic reviews, randomized controlled trials and clinical guidelines, using the MeSH terms “pain”, “paresthesia”, “hypoesthesia”, “carpal tunnel syndrome” and “alpha-lipoic acid”. The Strength of Recommendation Taxonomy scale was applied to classify articles into Levels of Evidence and Strengths of Recommendation.
RESULTS:
212 articles were obtained, of which 3 randomized controlled trials met the inclusion criteria, totaling 218 studied individuals. The 3 randomized controlled trials report some symptomatic improvement with administration of alpha-lipoic acid compared to placebo.
CONCLUSIONS:
There seems to be some benefit from the administration of alpha-lipoic acid in the symptomatic treatment of Carpal Tunnel Syndrome. More randomized controlled trials are needed with more homogeneous methodologies, a greater number of participants and a longer follow-up.
Keywords : Alpha-lipoic acid; Review; Carpal tunnel syndrome.