Abstract

VAZ-DE-MACEDO, Carolina  and  CLODE, Nuno. sFlt-1/PlGF ratio as a predictor of pre-eclampsia in the second and third trimesters of pregnancy: is clinical use supported by the evidence?. Acta Obstet Ginecol Port [online]. 2017, vol.11, n.2, pp.76-79. ISSN 1646-5830.

Pre-eclampsia is a common and potentially serious disorder of pregnancy. An antiangiogenic state appears to be central to its development. In particular, the sFlt-1/PlGF ratio increases in pre-eclampsia, leading to its potential use as a marker for prediction and diagnosis. Immunoassays for the sFlt-1/PlGF ratio are now commercially available and can assist in the diagnosis of women with a clinical suspicion of pre-eclampsia, leading to a decrease in hospital admissions. Remarkably, information is missing on the impact of its use in pregnancy outcomes

Keywords : Preeclampsia; Diagnosis; Placenta growth factor; Soluble vascular endothelial growth; Factor receptor-1; human; Decision support techniques.

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