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GE-Portuguese Journal of Gastroenterology
Print version ISSN 2341-4545
Abstract
MATOS, Andreia Carvalho de et al. Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung Disease. GE Port J Gastroenterol [online]. 2022, vol.29, n.4, pp.51-57. Epub Jan 02, 2023. ISSN 2341-4545. https://doi.org/10.1159/000516940.
Antibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin-induced autoimmune hepatitis and lung fibrosis that fulfills the definitive clinical criteria for diagnosis, presenting histological, imagiological, and immunological evidence of nitrofurantoin-induced toxicity. It occurred in a 68-year-old woman with extended nitrofurantoin intake for urinary tract infection prophylaxis who presented with progressive exercise dyspnea and jaundice. Similar published cases are also reviewed in this article.
Keywords : Autoimmune hepatitis; Nitrofurantoin toxicity; Interstitial pulmonary disease.