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Jornal Português de Gastrenterologia
versión impresa ISSN 0872-8178
Resumen
MURINELLO, António; TOME, Teresa; GOULAO, Augusto y COHEN, Álvaro. Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum. J Port Gastrenterol. [online]. 2010, vol.17, n.3, pp.116-125. ISSN 0872-8178.
CLINICAL REPORT: A patient diagnosed Wilsons disease (WD) 22 years previously, successfully treated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilsons disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.
Palabras clave : Wilsons disease; zinc; corpus callosum agenesis; hypocupremia.