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Jornal Português de Gastrenterologia
versión impresa ISSN 0872-8178
Resumen
VALENTE, Isabel et al. Intractable Diarrhea: Microvillous Inclusion Desease in a Newborn Infant. J Port Gastrenterol. [online]. 2011, vol.18, n.6, pp.298-302. ISSN 0872-8178.
Congenital defects of the intestinal mucosa cause severe diarrhoea in the neonatal period with important nutritional impact and subsequent dependency on parenteral nutrition. We present a case of a newborn female with protracted watery diarrhoea, severe dehydratation and persistent metabolic acidosis despite bowel rest, requiring parenteral nutrition. After extensive investigation including microbiologic, immunologic and metabolic studies, the diagnosis of microvillous inclusion disease was done, on the basis of histological and immunohistochemical features observed in a duodenal biopsy, showing intracytoplasmatic inclusions in the apical pole of the cytoplasm of enterocytes and effacing of the brush border. Intestinal transplantation may be the only treatment for this rare intestinal disorder
Palabras clave : Protracted diarrhoea; Newborn; Microvillous inclusion disease.