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Portuguese Journal of Nephrology & Hypertension

 ISSN 0872-0169

TEIXEIRA, Catarina; COSTA, Ana Cortesao    ALMEIDA, Edgar A. F. de. Recent trials in autosomal dominant polycystic kidney disease. []. , 28, 3, pp.193-200. ISSN 0872-0169.

^len^aAfter two decades of major achievements in the understanding of genetics and pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) several Stage III randomized and controlled clinical trials involving thousands of patients had the results published recently. In this article, the authors review the results of the major clinical trials discussing the clinical outcomes, adverse effects and limitations as well as the future directions in this exciting investigation.^lpt^aApós duas décadas de intensa investigação no domínio da genética e da fisiopatologia da doença poliquística renal autossómica dominante foram publicados os resultados de alguns ensaios clínicos aleatorizados e controlados envolvendo milhares de doentes. Neste artigo os autores revêm e discutem os resultados clínicos, os efeitos adversos e as limitações destes estudos bem como antevêm as futuras linhas de investigação neste domínio.

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