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Portuguese Journal of Nephrology & Hypertension

 ISSN 0872-0169

PIMENTEL, Ana et al. When acute interstitial nephritis has systemic involvement: TINU syndrome. []. , 29, 4, pp.35-356. ISSN 0872-0169.

^len^aTubulointerstitial nephritis is commonly related with the use of medication or the presence of infection. When uveitis precedes, follows or simultaneously occurs, a distinct and rare syndrome develops as part of the systemic illness. The initial investigation of tubulointerstitial and uveitis syndrome should exclude other systemic diseases that affect the eye and kidney. The diagnosis must include histopathological and clinical findings. The clinical course and treatment may rely on immunomodulatory agents. Case: 24-year old obese male admitted with rapidly progressive renal insufficiency without any identified precipitant factor that responded well to intravenous metilprednisolone. Renal biopsy revealed acute tubulointerstitial nephritis. Uveitis appeared when systemic steroids were tapered^lpt^aA nefrite tubulointersticial está frequentemente associada ao uso de fármacos ou à presença de infeção. Quando há uveíte que precede, acompanha ou surge posteriormente à nefrite, existe confirmação de uma distinta e rara síndrome com envolvimento sistémico. A investigação inicial da síndrome de nefrite intersticial e uveíte inclui a exclusão de outras doenças sistémicas com envolvimento ocular e renal. O diagnóstico baseia-se em achados histopatológicos e clínicos. A própria evolução clínica e o tratamento podem vir a depender de agentes imunomoduladores. Caso: Homem obeso de 24 anos, internado por insuficiência renal rapidamente progressiva, sem nenhum factor precipitante identificado, que respondeu favoravelmente a metilprednisolona endovenosa. A biopsia renal revelou nefrite tubulointersticial aguda. Aquando do desmame da corticoterapia sistémica desenvolveu uveíte

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