CARVALHO, Marisa et al. Aleukemic Leukemia. []. , 19, 4, pp.282-284. ISSN 0872-0754.

Introduction: The term aleukemic leukemia is used when there is skin infiltration by malignant leukocytes in the absence of blasts in peripheral blood and bone marrow, and it can be the first signal of the disease. Infiltration of the skin has been documented in 25-30% of patients with congenital leukemia. Leukemia cutis may be the first manifestation of congenital leukaemia, and may even precede blood or bone marrow leukaemia by several weeks or months. Most are associated with the myeloid lineage. The presence of mixed-lineage leukemia (MLL) gene has been associated with poor prognosis, requiring treatment with intensive chemotherapy. Case report: The authors report the case of a six-year-old black female, with skin lesions for three months, consistent with Acute Lymphoblastic Leukemia. Admitted in our Pediatric Department - Instituto de Oncologia do Porto - Portugal, by mother’s request, for chemotherapy. Discussion: Although a poor prog­nosis is usually associated with this situation, our patient had a good response to treatment

: Aleukemic leukemia; malignant cutaneous inltration; MLL gene.

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