Revista de Enfermagem Referência
ISSN 0874-0283 ISSN 2182-2883
SANTOS, Eduardo; CARDOSO, Daniela APOSTOLO, João. How to measure and explore heterogeneity in a meta-analysis: Key methodological strategies. []. , serVI, 1, e21077. 10--2022. ISSN 0874-0283. https://doi.org/10.12707/rv21077.
Background:
Systematic reviews including several studies will have some diversity, even if they address a similar topic. Studies have different designs, participants, interventions/exposures, and expected outcomes. This diversity is called heterogeneity. For its relevance, we will put forward some methodological strategies to measure and explore it.
Objective:
To demonstrate how to measure and explore heterogeneity in a meta-analysis.
Main topics under analysis:
We present the concept of heterogeneity in meta-analysis, as well as its types, measurement models, and conditions for its application. We also put forward several methodological options for exploring heterogeneity, using practical examples to operationalize them.
Conclusion:
Exploring heterogeneity in a meta-analysis is an essential step in the development of a systematic review to increase the consistency of its results and, consequently, the strength of its recommendations.
: meta-analysis; review literature as topic; effectiveness; epidemiologic methods; evidence-based practice.