CK Sérica é modulada por exercício mas não por suplementação de creatina 

 

Marco Machado

Felipe Sampaio-Jorge

André Teixeira- Ferreira

Franz W. Knifis

 

Laboratório de Fisiologia e Biocinética Universidade Iguaçu (UNIG, Itaperuna)

 

 

Resumo

Exercícios são indutores de aumentos na concentração sérica de CK, indicador de microlesões, sendo especulado que o uso da suplementação de creatina potencializaria este efeito. O objetivo deste estudo foi verificar se a suplementação de creatina modifica a concentração de CK em sedentários submetidos a exercícios. Vinte e sete homens sedentários, entre 18 e 25 anos participaram de um estudo duplo-cego placebo controlado. No primeiro dia todos foram submetidos a uma avaliação cineantropométrica e nutricional e posteriormente divididos aleatoriamente em 2 grupos: C (n = 15) e P (n = 12). Depois da suplementação todos foram submetidos a um programa de 5 exercícios (3x10 repetições) a 85% de 1RM. Os sujeitos tiveram a concentração de CK medida antes da suplementação, imediatamente antes, 4h e 24h após os exercícios. Houve aumento na MCT dos sujeitos suplementados com creatina (0,7 ± 0,3 kg). Não houve aumento da variação da concentração de CK medida após a suplementação e após o exercício, contudo a concentração de CK aumentou 24h após em ambos os grupos (253 ± 27% no grupo C e 262 ± 31% no grupo P). A diferença da concentração de CK pós-exercício (24h) foi maior em ambos os grupos analisados neste estudo sem, no entanto mostrar efeito da suplementação.

Palavras chave: microlesão muscular; lesão induzida por exercício; suplementação de creatina; CK

 

Serum CK concentration is modulated by exercise but not creatine supplementation

Abstract

Exercises are inductive of increases in serun CK concentration, microinjuries marker, being speculated that the use of creatine supplementation would increases this effect. The aim of this study was to verify if creatine supplementation modifies the concentration of CK in sedentary submitted the exercises. Twenty seven sedentary men, between 18 and 25 years had participated of controlled a double-blind study placebo. In the first day all had been submitted to a evaluation and later divided in 2 groups: C (n = 15) and P (n = 12). After the supplementation all had been submitted to a program of 5 exercises (3x10 repetitions) 85% of 1RM. The subjects had the concentration of CK measured before the suplementação, immediately before, 4h and 24h after the exercises. It had increase in the MCT of the subjects supplemented with creatine (0,7 ± 0,3 kg). the variation of the concentration of CK did not have increase of measured after the supplementation and after the exercise, however the CK concentration after increased 24h in both the groups (253 ± 27% in 262 group C and ± 31% in group P). The difference of the CK concentration after-exercise (24h) was bigger in both the groups analyzed in this study without, however to show effect of the supplementation.

Key words: muscle damage; exercise induced injury; creatine supplementation; CK

 

 

Texto completo disponível apenas em PDF

Full text only available in PDF

 

 

Referências

1. Brudnak MA. (2004) Creatine: are the benefits worth the risk? Toxicol Lett. 150(1):123-130.        [ Links ]

2. Clarkson PM, Hubal MJ. (2002) Exercise-induced muscle damage in humans. Am J Phys Med Rehabil. 81(11 Suppl):S52-S69.

3. Dennehy CE; Tsourounis C; Horn AJ. (2005) Dietary supplement-related adverse events reported to the California Poison Control System. Am. J. Health Syst. Pharm. 62(14):1476-1482.

4. Doherty M; Smith PM; Davison RCR; HughesMG. (2002) Caffeine is ergogenic after supplementation of oral creatine monohydrate. Med Sci Sports Exerc. 34(11):1785-1792.

5. Groeneveld GJ; Beijer C; Veldink JH; Kalmijn S; Wokke JH; Vandenberg LH. (2004) Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int J Sports Med. 24(4):307-313.

6. Hootman JM; MaceraCA; Ainsworth BE; Addy CL; Martin M; Blair SN. (2002) Epidemiology of musculoskeletal injuries among sedentary and physically active adults. Med Sci Sports Exerc. 34(5):838-844.

7. Izquierdo M; Ibañez J; González-Badillo JJ; Gorostiaga EM. (2002) Effects of creatine supplementation on muscle power, endurance, and sprint performance. Med Sci Sports Exerc. 34(2):332-343.

8. Järvinen TAH; Järvinen TLN; Kääriäinen M; Kalimo H; Järvinen M. (2005) Muscle Injuries - Biology and Treatment. Am J Sports Med. 33(5):745-763.

9. Kreider RB; Melton C; Rasmussen CJ; Greenwood M; LancasterS; Cantler EC. et al. (2003) Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Mol. Cell Biochem. 244(1-2):95-104.

10. Lemon PWR. (2002) Dietary creatine supplementation and exercise performance: Why inconsistent results? Can J Appl Physiol. 27(6):663-680.

11. Magaudda L; Di Mauro D; Trimarchi F; Anastasi G. (2004) Effects of Physical Exercise on Skeletal Muscle Fiber: Ultrastructural and Molecular Aspects. Basic App Myol. 14(1):17-21.

12. Matthews RT; Yang L; Jenkins BG; Ferrante RJ; Rosen BR; Kaddurah-Daouk R; Beal MF. (1998) Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease. J Neuroscience. 18(1):156-163.

13. Mihic S; Macdonald JR; Mackenzie S; Tarnopolsky M. (2000) A. Acute creatine loading increases fat-free mass, but not affect blood pressure, plasma creatine, or CK activity in men and women. Med. Sci. Sports Exerc. 32(2):291-96.

14. Nosaka K; Newton M; Sacco P. (2002) Muscle damage and soreness after endurance exercise of the elbow flexors. Med Sci Sports Exerc. 34(6):920-927.

15. Paddon-Jones D; Borsheim E; Wolfe RR. (2004) Potential ergogenic effects of arginine and creatine supplementation. J. Nutrition. 134(10):2888S-2894S.

16. PaschalisV; Koutedakis Y; Jamurtas AZ; Mougios V; Baltzopoulos V.  (2005) Equal volumes of high and low intensity of eccentric exercise in relation to muscle damage and performance. J Strength Cond Res. 19(1):184-188.

17. Phillips T; Childs AC; Dreon DM; Phinney S; Leeuwenburgh C. (2003) A Dietary Supplement Attenuates IL-6 and CRP after Eccentric Exercise in Untrained Males. Med Sci Sports Exerc. 35(12):2032-7.

18. Rawson ES; Gunn B; Clarkson PM. (2001) The effects of creatine supplementation on exercise-induced muscle damage. J Strength Cond Res. 15(2):178-184.

19. Robinson TM; Sewell DA; Casey A; Steenge G; Greenhaff PL. (2000) Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br J Sports Med. 34(4):284-288

20. Rosalki SB. (1967) An improved procedure for serum creatine phosphokinase determination. J Lab Clin Méd. 69(4):696-705.

21. SBME. (2003) Diretriz da Sociedade Brasileira de Medicina do Esporte - Modificações dietéticas, reposição hídrica, suplementos alimentares e drogas: comprovação de ação ergogênica e potenciais riscos para a saúde. Rev Bras Med Esporte. 9(2):43-56.

22. Stupka N; Lowther S; Chorneyko K; Bourgeois JM; Hogben C; Tarnopolsky MA. (2000) Gender differences in muscle inflammation after eccentric exercise. J Appl Physiol. 89(6):2325-2332.

23. Volek JS; Rawson ES. (2004) Scientific basis and practical aspects of creatine supplementation for athletes. Nutrition. 20(7-8):609-614.

24. Wyss M. (2004) Writing about creatine: is it worth the risk? Toxicol Lett. 152(3):273-274.

 

 

Data de submissão: Dezembro 2007

Data de Aceite: Abril 2007

 

 

Correspondência:

Marco Machado

Laboratório de Fisiologia e Biocinética (UNIG – Campus V)

BR 356 - Km 02 Itaperuna, RJ, 28.300-000

Brasil

marcomachado1@gmail.com