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Revista Portuguesa de Imunoalergologia
versão impressa ISSN 0871-9721
Resumo
VASCONCELOS, Maria João et al. Desensitization to carboplatin and methotrexate in children: An allergy department review. Rev Port Imunoalergologia [online]. 2023, vol.31, n.3, pp.205-215. Epub 30-Set-2023. ISSN 0871-9721. https://doi.org/10.32932/rpia.2023.08.116.
Background:
Hypersensitivity reactions during chemotherapy have been increasingly documented in children. Drug desensitization is an unknown procedure for most oncologists, despite allowing patients to be treated with first-line agents, affecting the final prognosis. Currently, there are no guidelines for drug desensitization in pediatric age, and the general principles adopted for adults have been applied to children.
Objective:
To describe the experience of an Immunoallergology department of a central hospital in the desensitization to carboplatin and methotrexate in pediatric age.
Results:
Desensitizations were performed on carboplatin in 17 patients, in a total of 112 procedures, and on methotrexate in 4 children, with a success rate of 88% for carboplatin and 100% for methotrexate.
Conclusion:
As far as the authors are aware, this is the largest European series of desensitizations to chemotherapy in pediatric age, including procedures in infants and in non-immediate reactions.
Palavras-chave : Antineoplastics; carboplatin; children; desensitization; hypersensitivity; methotrexate; oncology.