Adsorptive and Catalytic Cathodic Stripping Voltammetric Determination of Timonacic

 

O.A.R. Amin,^1,* S.F. Belal² and R. Bakry³

¹ Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdulaziz University, Saudi Arabia.

² Pharmaceutical Analytical Chemistry, Department, Faculty of Pharmacy, University of Alexandria, Egypt.

³ Institute of Analytical Chemistry and Radiochemistry, Leopold Franzens University Innsbruck, Innrain 52a, 6020 Innsbruck, Austria.

 

DOI: 10.4152/pea.201102115

 

Abstract

Two sensitive voltammetric techniques (adsorptive and catalytic cathodic stripping) are described for the determination of timonacic, in the presence of copper or nickel ions, respectively. The measured peaks which correspond to the reduction or copper (I) or nickel – timonacic complexes are measured at -773 and -782 mV, respectively. The different experimental parameters have been carefully studied. The methods have been fully validated. The detection limits were 1.5 and 13.6 ng mL^-1, respectively. The methods have been applied for the determination of timonacic in pharmaceutical tablets. The obtained results have been compared statistically with those obtained from a published method.

Keywords: timonacic; adsorptive stripping voltammetry; catalytic cathodic stripping voltammetry; pharmaceutical tablets.

 

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* Corresponding author. E-mail address: omarazak_amin@yahoo.com

Received 13 October 2010; accepted 31 March 2011