Tumor de células granulares endobrônquico – Como abordamos?

Endobronchial granular cell tumor – What approach to take?

Ana Rego¹

Joana Amado²

Idália Esteves³

José Almeida²

Antónia Furtado⁴

António Couceiro⁵

João Moura e Sá³

 

 

Resumo

O tumor de células granulares é uma neoplasia de origem mesenquimatosa, quase sempre benigna, mas com tendência a recidivar. Embora surja com maior frequência na cabeça e no pescoço, tem sido descrito em quase todas as áreas do corpo. A sua ocorrência no pulmão é extremamente rara.

Os autores descrevem dois casos de tumores endobrônquicos de células granulares, discutem os aspectos particulares desta patologia, bem como as modalidades terapêuticas utilizadas, com particular ênfase no uso da excisão e crioterapia endobrônquica.

Palavras-chave: Tumor de células granulares, pulmão, crioterapia endobrônquica.

 

 

Abstract

Granular cell tumor is a mesenchymal neoplasm almost always benign, with tendency to recurrence. Although it is more frequent in in the head and neck it has been described in almost all areas of the body. Its occurrence in the lung is extremely rare. The authors describe two cases of endobronchial granular cell tumours, discuss the particularities of this pathology as well as the treatment options, with particular attention to the use of endobronchial excision and criotherapy.

Key-words: Granular cell tumour, lung, endobronchial criotherapy.

 

Texto completo disponível apenas em PDF.

Full text only available in PDF format.

 

Bibliografia

1. Abriokossoff A. Myomas originating from transversely striated voluntary musculature. Virchows Arch Pathol Anat 1926; 260:215-33.        [ Links ]

2. Garancis JC, Komoroowski RA, Kuzma JF. Granular cell myoblastoma. Cancer 1970; 25:542-50. 3. Desai DP, Maddalozzo J, Holinger LD. Granular cell tumor of the trachea. Otolaryngol Head Neck Surg 1999; 120:595-598.

4. Spandow O, Lindholm CE. Granular cell tumor in a child’s trachea – a diagnosis and therapeutic challenge. Pediatr Otorhinolaryngol 1994; 30:159-166.

5. Triguero DG, Rivero AR, González JA, Fernández RS. Laryngeal granular cell tumour. Acta Otorrinolaring Esp 1998; 49,2:148-150.

6. Al-Ghamid A, Flint JDA, Muller NL, et al. Hilar pulmonary granular cell tumor: a case report and review of the literature. Ann Thorac Surg 1976; 22:199-202.

7. De Clercq D, Van der Straeton M, Roels H. Granular cell myoblastoma of the bronchus. Eur J Respir Dis 1983; 64:72-74.

8. Deavers M, Guinee D, Koss MN, Travis WD. Granular cell tumour of the lung. Clinicopathologic study of 20 cases. Am J Surg Pathol 1995; 19:627-635.

9. Daniel TM, Smith RH, Faunce HV, Sylvest VM. Transbronchoscopic versus surgical resection of tracheobronchial granular cell myoblastomas. Suggested approach based on follow-up of all treated cases. J Thorac Cardiovasc Surg 1980; 80:898-903.

10. Epstein LJ, Mohsenifar Z. Use of Nd:YAG laser in endobronchial granular cell myoblastoma. Chest 1990; 98:945-948.

11. Sataloff RT, Ressue JC, et al. Granular Cell Tumors of the Larynx. Journal of Voice 2000; 14:119-134.

12. Young CD, Gay RM. Multiple endobronchial granular cell myoblastomas discovered at bronchoscopy. Hum Pathol 1984; 15:193-194.

13. Redjaee B, Rohatgi PK, Herman MA. Multicentric endobronchial granular cell myoblastoma. Chest 1990; 98:945-948.

14. Gabriel JB Jr, Thomas L, Kondlapoodi P, et al. Granular cell tumour of the bronchus: a previously unreported cause of hypercalcemia. J Surg Oncol 1983; 24:338-340.

15. Tamayo JL, Rojas MC. Granular cell myoblastoma of the right upper bronchus coexisting with bronchogenic carcinoma. J Thorac Cardiovasc Surg 1971; 62:268-270.

16. Cutlan RT, Eltorky M. Pulmonary granular cell tumor coexisting with bronchogenic carcinoma. Ann Diagn Pathol 2001; 5(2):74-79.

17. Muhammad AA, Sikka P, et al. Coexisting granular cell tumor and adenocarcinoma of the lung: a case report and review of the literature. Resp Care 2001; 46(7):702-704.

18. Glant MD, Wall RW, Ranburg R. Endobronchial granular cell tumor. Cytology of a new case and review of the literature. Acta Cytol 1979; 23:477-482.

19. Fuzesi L, Hoer PW, Schmidt W. Exfoliative cytology of multiple endobronchial granular cell tumor. Acta Cytol 1989; 33:516-518.

20. Husain M. Cytopathology of granular cell tumor of the lung. Diagnostic Cytopathology 2000; 23(4):294-295.

21. Kershisnik M, Batsakis B, Mackay B. Pathology consultation-granular cell tumors. Ann Otol Rhinol Laryngol 1994; 103:416-419.

22. Mills SE, Gaffey MJ, Frierson HF. Tumors of the upper aerodigestive tract and ear, third series, Armed Forces Institute o Pathology, Washington DC, 2000.

23. Stefansson K, Wollmann R, Jerkovic M. S-100 protein in soft-tissue tumors derived from Schwann cell and melanocytes. Am J Pathol 1981; 106:261-268.

24. McSwain GR, Colpitts R, Kreutner A, et al. Granular cell myoblastoma, Surg Gynecol Obstet 1980; 150:703-10.

25. Fanburg-Smith JC, Meis-Kindblom JM, Fante, Kindblom LG. Malignant granular cell tumor of soft tissue. Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22:779-794.

26. Jardine L, Cheung L, LiVolsi V, et al. Malignant granular cell tumors: report of a case and review of the literature. Surgery 1994; 116:49-54.

 

¹ Interna Complementar de Pneumologia

² Assistente Hospitalar de Pneumologia

³ Assistente Hospitalar Graduado de Pneumologia

⁴Interna Complementar de Anatomia Patológica

⁵ Chefe de Serviço de Anatomia Patológica

Serviço de Pneumologia do Centro Hospitalar de Vila Nova de Gaia. Director: Dr. Raul César Sá

Unidade de Broncologia do Centro Hospitalar de Vila Nova de Gaia. Responsável: Dr. João Moura e Sá

Serviço de Anatomia Patológica do Centro Hospitalar de Vila Nova de Gaia. Director: Dr. António Couceiro

 

Recebido para publicação/received for publication: 05.09.05

Aceite para publicação/accepted for publication: 06.04.26