Os factores genéticos da asma

Asthma genetic factors

 

Paula Alexandra Videira ¹

Luís Miguel Borrego ²

Hélder Trindade ³

 

Resumo

A asma brônquica é uma doença inflamatória crónica das vias aéreas, de prevalência crescente, particularmente na infância, sendo considerado um importante problema de saúde pública. É reconhecidamente uma doença de transmissão familiar, sendo um desafio a descrição e potencial identificação dos genes envolvidos na sua génese. Pretende-se com o presente artigo de revisão explicitar exaustivamente os genes associados a esta patologia, bem como esclarecer os métodos laboratoriais que permitem a sua identificação.

Palavras-chave: Asma, susceptibilidade genética, genome wide screen, estudos de associação, farmacogenética.

 

Abstract

Asthma is a chronic inflammatory airways disease, with a rising prevalence, particularly in childhood, and is considered an important Public Health problem. It’s familial transmission is recognised, while the description and identification of the genes implicated in this disease are a challenge. In this revision paper the authors give a comprehensive explanation of the associated genes as well as the laboratorial methods that allow their identification.

Key-words: Asthma, genetic susceptibility, genome wide screen, association studies, pharmacogenetics.

 

Texto completo disponível apenas em PDF.

Full text only available in PDF format.

 

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¹ Assistente Convidada Doutorada,

² Assistente Convidado. Assistente Hospitalar de Imunoalergologia do Hospital Dona Estefânia

³ Professor Associado Convidado com Agregação

 

Faculdade de Ciências Médicas, Departamento de Imunologia

Universidade Nova de Lisboa

Campo dos Mártires da Pátria, n.º 130

1169-056 Lisboa

Tel: 351-218803045/ 218853000

Fax: 218853480

 

Recebido para publicação/received for publication: 06.06.28

Aceite para publicação/accepted for publication: 06.07.30