Células reguladoras

Regulatory cells

 

Luís Miguel Borrego¹

Sónia Rosa²

Cármen Algueró³

Hélder Trindade⁴

José Rosado Pinto⁵

 

Resumo

O papel das células T reguladoras na indução e manutenção da tolerância periférica tem recebido uma atenção crescente nos últimos anos. Foram descritos vários subgrupos de células T reguladoras, com base em marcadores de superfície e na produção de citocinas, não havendo no entanto marcadores específicos para nenhum destes subgrupos, pelo que a sua classificação se baseia no seu mecanismo de supressão. Desconhece-se qual dos subgrupos de células T reguladoras terá papel preponderante na prevenção e controlo das doenças alérgicas, sendo no entanto consensual a sua importância para a homeostasia.

Palavras-chave: Doenças alérgicas, células T reguladoras, tolerância periférica.

 

Abstract

The role of regulatory T cells in the induction and maintenance of peripheral tolerance has received growing attention during the last years. Several subsets of regulatory T cells were described based on their surface markers and citokine production, but nevertheless, there are no specific markers for any subsets and their classification relies on their suppression mechanism. It is unknown which of the subgroups of regulatory T cells is more important in the prevention and control of allergic diseases, being commonly accepted its importance in homeostasis.

Key-words: Allergic diseases, peripheral tolerance, regulatory T cells.

 

 

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¹ Assistente Hospitalar de Imunoalergologia. Serviço de Imunoalergologia do Hospital de Dona Estefânia. Assistente Convidado do Departamento de Imunologia da Faculdade de Ciências Médicas de Lisboa.

² Interna do Internato Complementar de Imunoalergologia. Serviço de Imunoalergologia do Hospital de Dona Estefânia.

³ Assistente Convidada do Departamento de Imunologia da Faculdade de Ciências Médicas de Lisboa.

⁴ Professor Associado Convidado com Agregação do Departamento de Imunologia da Faculdade de Ciências Médicas de Lisboa.

⁵ Responsável pelo Serviço de Imunoalergologia do Hospital de Dona Estefânia. Professor Auxiliar convidado da Faculdade de Ciências Médicas de Lisboa.

 

Serviço de Imunoalergologia – Hospital de Dona Estefânia:

Rua Jacinta Marto – 169-045 Lisboa – E-mail: hde.imunoalergo@mail.telepac.pt – Tel: +351213126600 / Fax: +351213126654

Faculdade de Ciências Médicas - Universidade Nova de Lisboa:

Departamento de Imunologia, Campo dos Mártires da Pátria, n.º 130 1169-056 Lisboa – Tel: 351-218803045/ 218853000 / Fax: 218853480

 

Recebido para publicação/received for publication : 06.11.23

Aceite para publicação/accepted for publication : 07.02.20