Abstract

ESTEVES, Gonçalo  and  CARNEIRO, Fátima. Primary sclerosing cholangitis and ulcerative colitis: Facts and uncertainties. Arq Med [online]. 2013, vol.27, n.5, pp.212-221. ISSN 2183-2447.

Primary sclerosing cholangitis and inflammatory bowel disease, mainly ulcerative colitis, are in some way interconnected. The latter presents some phenotypical changes to its classical presentation when associated with the former. Besides, there are additional demands when handling patients with these diseases, as reflected for instance by the distinct risk of neoplasia, which is difficult to ascertain. The splitting of primary sclerosing cholangitis in two groups, a colitis- associated one and an isolated one, is still controversial. lately there has been investigation on how to diagnose these associated diseases through autoantibodies titres and susceptibility genes, but no straightforward results were reached yet. Here we assemble the up-to-date data on this Gastroenterology/Hepatology issue.

Keywords : Sclerosing cholangitis; inflammatory bowel diseases; ulcerative colitis; colorectal cancer.

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