Abstract

LOUREIRO, Carlos et al. Values of resistin, adiponectin and leptin in overweight patients with asthma. Rev Port Imunoalergologia [online]. 2012, vol.20, n.2, pp.121-128. ISSN 0871-9721.

In recent years, there has been an increased prevalence of asthma and obesity. Asthma is a chronic inflammatory disease of the airways. Obesity represents an imbalance between energy intake and the amount of energy expended, resulting in a excess of body fat that can affect health. Epidemiological studies have argued that obesity increases the risk of developing asthma, even for low values of excessive weight. Despite the knowledge of the association between asthma and obesity, the underlying mechanisms are not yet totally understood. The aim of this study was to evaluate the values of the adipokines produced by adipose tissue - resistin, adiponectin and leptin - in overweight and normal weight patients, with and without asthma. In this study, 28 asthmatic overweight, 26 non -asthmatics overweight and 26 asthmatics with normal weight were evaluated. The body mass index, the abdominal circumference, skin prick tests for allergy were performed in all the population, and it was also determined the serum concentration of resistin, adiponectin and leptin. The comparison between the three groups revealed that leptin levels are significantly different, being higher in overweight asthmatics. The presence of allergy was associated with higher levels of leptin, but without statistical significance. The concentrations of adiponectin were very similar among the three groups. The resistin was higher in women with greater abdominal diameter. The results indicate a change at the systemic level of adipokines in overweight patients with asthma, particularly in women with potential impact on respiratory status.

Keywords : Adipokines; adiponectin; asthma; BMI; leptin; obesity; resistin.

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