Abstract

MOSCOSO, Teresa; PAES, Maria João  and  NETO, Marta. Acute interstitial nephritis induced by piperacillin-tazobactam?. Rev Port Imunoalergologia [online]. 2013, vol.21, n.3, pp.207-212. ISSN 0871-9721.

Acute interstitial nephritis (AIN) represents an important cause of renal failure. The majority of AIN cases have been linked to drugs, given its increased use. We report our experience in managing a 61-year-old woman with AIN and subsequent renal injury following a piperacillin -tazobactam intake. The diagnosis was based on clinical presentation by using the “Naranjo probability” scale for adverse reactions to drugs. Renal biopsy, although considered the gold standard for diagnosis of AIN, is not needed in all patients. In patients for whom the diagnosis seems likely, for whom a probable precipitating drug can be easily withdrawn, and who improve readily after withdrawal of a potentially offending drug, supportive management can proceed safely without renal biopsy. Regarding the aging population and the increasing number of polymedicated patients with multiple comorbidities, it becomes important to consider this diagnosis when in presence of acute renal failure. The aim of our report is to increase awareness to the potential involvement of this semi-synthetic beta -lactam in less common hypersensitivity reaction such as AIN.

Keywords : Acute interstitial nephritis; acute renal failure; drug induced hypersensitivity; piperacillin-tazobactam.

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