Abstract

COSME, Joana; SANTOS, Amélia Spínola  and  BARBOSA, Manuel Pereira. Tropomyosin as a panallegen: Review. Rev Port Imunoalergologia [online]. 2016, vol.24, n.3, pp.143-153. ISSN 0871-9721.

Tropomyosin is a panallergen involved in cross-sensitivity reactions between, invertebrates, being of particular epidemiological importance, the cross-reactivity between house dust mites and crustaceans. Based on a literature review about tropomyosin hypersensitivity, firstly there is made a description of the structure and function of this protein and afterwards the tropomyosin allergens described in the literature as well as the degree of homology between the shrimp tropomyosin and tropomyosin from other allergen sources are presented. The results of the main studies about tropomyosin sensitization prevalence which shows that tropomyosin sensitization varies according with the protein source and with the geographical area considered are also revised. Finally, there are presented the results of some studies that emphasize the importance of using in vitro determination of tropomyosin specific IgE as an additional diagnostic tool in shrimp allergy diagnosis.

Keywords : Cross-reactivity; diagnosis tool; panallergen; sensitization; tropomyosin.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )