Abstract

PAIXAO, Ana; CALDEIRA, Joana; LEOCADIO, João  and  MARTINS, Luís. The importance of skin barrier integrity for the prevention of veterinary allergy. Rev Port Imunoalergologia [online]. 2022, vol.30, n.1, pp.9-20.  Epub Mar 21, 2022. ISSN 0871-9721.  https://doi.org/10.32932/rpia.2022.03.074.

One important motivation for veterinary consultation is related to dermatological conditions, being pruritus a frequent complaint. Allergic-based conditions associated with inflammatory erythema and various complications, such as alopecia and secondary infections, are commonly associated. Assessing the level of the skin barrier and restoring its effect is essential. Defects in skin lipid and protein constitution contribute in humans and animals to the reduction of the barrier function, favoring deep penetration of different agents. Penetration by allergens or microorganisms triggers an immune response with more or less inflammation and itching, in a context in which the genetic predisposition to sensitization and allergy plays a fundamental role. Constitutional similarities, relevant for the skin barrier effect, have been identified between humans and dog, associated with allergic susceptibility, and may constitute a two-way model in a society where, sharing the space, they both subject to the same exposome.

Keywords : Skin; allergy; atopy; skin barrier; dog; cat; horse.

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