Abstract

QUELHAS-SANTOS, Janete. Is renalase a new regulator of renal dopaminergic activity?. Port J Nephrol Hypert [online]. 2014, vol.28, n.1, pp.31-39. ISSN 0872-0169.

Dopamine (DA) of renal origin behaves as an endogenous natriuretic hormone decreasing tubular sodium reabsorption as a paracrine/autocrine substance and contributing to blood pressure control. The availability of renal DA is determined by the interplay between the rate of synthesis and the degree of degradation of the amine. The degradation of renal DA is well recognized to be mediated by two main enzymes - types A and B monoamine oxidases (MAO-A and MAO-B) and catechol-O-methyltransferase (COMT). In studies aimed at reducing the degradation of renal DA, both the selective and combined inhibition of MAO-A and COMT, did not change renal DA excretion or natriuresis, notwithstanding the marked decrease observed in the urinary excretion of the corresponding deaminated and methylated metabolites. This observation suggested that other metabolic pathways in addition to COMT and MAO might be involved in the regulation of renal dopamine output. Renalase, a new kidney-secreted catecholamines-degrading enzyme, is endowed with potent hypotensive effects when administered in vivo and may represent a new player in the regulation of the renal dopamine system.

Keywords : Chronic kidney disease; natriuresis; renal dopamine system; renalase.

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