Resumo

FERNANDEZ-REYES, MJ et al. Aldosterone levels in patients on haemodialysis: Relationship with body fat mass and adipocytokines. Port J Nephrol Hypert [online]. 2016, vol.30, n.3, pp.199-204. ISSN 0872-0169.

Background: It has been recently shown that serum aldosterone (SA) levels are correlated with insulin resistance, excess body fat and levels of adipocytokines. Aim: To establish SA levels in patients on haemodialysis (HD) and the possible association with excess body fat and/or serum adipocytokine levels. Methods: 28 stable patients on HD. Mean age: 73.7±13.3 years; 53.6% men. Mean time on HD: 40.2± 40.8 months. None were diabetics nor treated with drugs that interfere with the renin-angiotensin-aldosterone-system. 18 patients were anuric. All measurements were performed prior to the midweek HD session. Results: SA levels (median: 28.1; 25th percentile (p25):10.4; 75th percentile (p75):98.6 ng/dl) were above the normal range in 53.6% of patients. Plasma renin activity (PRA) (median: 1.05; p25: 0.16; p75: 3.1 ng/mL/hour) was above the normal range in 21.4% of patients. There were no statistically significant differences in SA levels between anuric and non-anuric, male and female, presence and absence of myocardiopathy. There were no statistically significant correlations of SA levels or PRA with urine volume, residual renal function, dose or time on dialysis. age, or comorbidity. SA levels were positively correlated with PRA (r=000.70; p< 0.0001); body fat mass (r=0.40; p=0.03); leptin (r=0.45; p =0.01); leptin/adiponectin ratio (r=0.52 p=0.005) and negatively with serum adiponectin levels (r=- 0.37; p=0.05). In stepwise multiple regression analysis, the best model to explain SA levels included PRA and LAR (r=0.78; r2=0.60). Conclusions: SA levels were elevated in a high percentage of HD patients. SA levels were correlated with PRA, body fat mass and adipocytokines

Palavras-chave : Aldosterone; haemodialysis; adiponectin; leptin; boy mass fat.

        · texto em Inglês     · Inglês ( pdf )