SciELO - Scientific Electronic Library Online

 
vol.36 número1Case series of COVID-19 in chronic kidney disease patients under peritoneal dialysis at a northern Portuguese centerEarly mortality in incident hemodialysis patients - A retrospective case-control study índice de autoresíndice de assuntosPesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Portuguese Journal of Nephrology & Hypertension

versão impressa ISSN 0872-0169

Resumo

ROLDAO, Marisa et al. Predictors of hyporesponsiveness to erythropoietin in prevalente hemodialysis patients and its association with mortality. Port J Nephrol Hypert [online]. 2022, vol.36, n.1, pp.35-39.  Epub 30-Mar-2022. ISSN 0872-0169.  https://doi.org/10.32932/pjnh.2022.03.168.

Introduction: Erythropoietin-stimulating agents hyporesponsiveness is common among hemodialysis patients. The aim was to analyze factors predictive of Erythropoietin-stimulating agent resistance and its association with mortality. Subjects and methods: Retrospective analysis of prevalent hemodialysis patients. Dose-response effect of Erythropoietin-stimulating agent therapy was evaluated using Erythropoietin-stimulating agent resistance index (ERI). Patients were classified in groups (ERI≤10 and ERI>10). All-cause mortality was assessed using standard survival methods. Results: Among 59 patients, 24 had ERI>10. Patients with ERI >10 had more central venous catheters, higher C-reactive protein levels, lower body mass index, serum iron, transferrin saturation, albumin and intact parathormone levels. Hyporesponsive patients had an increased risk of one-year mortality. Discussion and conclusion: Our study confirmed that malnutrition, inflammation, and iron deficiency are the main causes of Erythropoietin-stimulating agent hyporesponsiveness, and intact parathormone levels and central venous catheter use may also play a role. Erythropoietin-stimulating agent resistance appear to be associated with an increased mortality risk among prevalent hemodialysis patients.

Palavras-chave : ESA hyporesponsiveness; ESA resistance index; hemodialysis; anemia; inflammation.

        · texto em Inglês     · Inglês ( pdf )