Abstract

FIGUEIREDO, Cátia Raquel et al. Pediatric Nephrotoxicity: How Aware Are We?. Port J Nephrol Hypert [online]. 2023, vol.37, n.2, pp.57-59.  Epub June 30, 2023. ISSN 0872-0169.  https://doi.org/10.32932/pjnh.2023.04.236.

Vancomycin and aminoglycosides are potentially nephrotoxic broad-spectrum antibiotics, which can be used both in the treatment of severe infections and in surgical prophylaxis, in pediatric patients. Prolonged antibiotic therapy and high trough concentrations are associated with toxicity. Additionally, several individual factors contribute to nephrotoxicity increasing the risk of acute kidney injury (AKI) and consequente chronic kidney disease in the future. We developed a retrospective and observational study in the Pediatrics Department of a tertiary hospital in Portugal, to analyze clinical practice regarding monitoring and surveillance of vancomycin and aminoglycosides. The results showed low rates of monitoring, which reinforces the importance of raising awareness about this issue, recognizing its importance, and adopting preventive measures that may mitigate the risk of toxicity and improve children’s renal prognosis in adult life.

Keywords : Acute Kidney Injury/complications; Aminoglycosides/adverse effects; Child; Kidney/drug effects; Kidney Diseases/chemically induced; Renal Insufficiency, Chronic/chemically induced; Vancomycin/adverse effects.

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