Abstract

OLIVEIRA, Ana Isabel et al. Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report. Port J Nephrol Hypert [online]. 2023, vol.37, n.2, pp.112-115.  Epub June 30, 2023. ISSN 0872-0169.  https://doi.org/10.32932/pjnh.2023.07.243.

Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was performed, showing minimal change disease with lymphomatous infiltration of B-lymphocytes CD20+. Therapy with bortezomib, dexametahasone and rituximab was started and after 6 months of follow-up he presented progressive recovery of renal function and remission of proteinuria.

This case illustrates the importance of screening renal disease in WM patients. A kidney biopsy should be performed in those presenting with otherwise unexplained renal failure and/or nephrotic syndrome.

Keywords : Biopsy; Kidney/pathology; Nephrotic Syndrome; Waldenstrom Macroglobulinemia.

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