Abstract

MATOS, Catarina et al. Paroxismal cold hemoglobinuria: when to suspect?. Nascer e Crescer [online]. 2012, vol.21, n.3, pp.135-137. ISSN 0872-0754.

Introduction: The paroxysmal cold hemoglobinuria is a rare form of presentation of autoimmune hemolytic anemia. Case report: We describe the case of a 23 months-old child with jaundice and dark urine of sudden onset. There was refer­ence to upper respiratory infection a week earlier. He presented severe anemia with hemoglobinuria. DHL was rised and the di­rect Coombs test was positive with specific anti-C3d. The positive of Donath-Landsteiner proof, to demonstrate the biphasic nature of the autoantibody, confirmed the diagnosis of paroxysmal cold hemoglobinuria. Conclusion: With this case report the authors aim to high­light the importance of recognizing this condition and the char­acter of intravascular hemolysis, so that quicker diagnosis and treatment can be made.

Keywords : Cold exposure; paroxysmal cold hemoglobinu­ria; intravascular hemolysis; pediatric age.

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