Abstract

ANTUNES, Joaquina et al. Phenytoin: boundaries of the treatment. Nascer e Crescer [online]. 2014, vol.23, n.2, pp.95-99. ISSN 0872-0754.

Introduction: Seizures are rather common in the neonatal period. It still remains unclear what is the best therapeutic approach, and there is no consensus protocol. Currently used antiepileptic drugs are sometimes ineffective and may cause significant adverse effects. Case report: We present the case of a newborn with seizures during the first day of life. After unsuccessful treatment with phenobarbital, phenytoin was added. He developed a picture of encephalopathy due to intoxication with this drug, despite the use of standard dosages. Given unchanged further investigations, individual’s susceptibility was considered to be the cause. Conclusion: Because of potential side effects, more frequent and severe in newborns, phenytoin tends to be less used in the treatment of neonatal seizures. Benzodiazepines and lidocaine seems to be safer and more effective options.

Keywords : Neonatal seizures; phenytoin; toxicity.

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