Resumen

COSTEIRA, Mónica André et al. Oral challenge to drugs in Pediatrics: Casuistry 2015. Nascer e Crescer [online]. 2017, vol.26, n.4, pp.216-220. ISSN 0872-0754.

Introduction: Suspected drug allergy in the pediatric population is a frequent reason for consultation. However, it is rarely confirmed. Thus, the oral challenge (OC) assumes a significant role in the diagnostic approach. Objectives: Characterize a pediatric population of a level II hospital submitted to OC to drugs, assess which drugs where implicated and analyze the cases in which the OC was positive. Materials and methods: Clinical records of the patients submitted to OC to drugs in the period of January 1^st to December 31^st 2015, younger than 18 years. Results: The sample included 58 patients, 53.4% male. The median age was five years. Most were referred from the emergency room (39.7%) and the outpatient clinic (36.2%). Amoxicillin was the suspected drug in 46.6% and when associated with clavulanic acid in 34.5%. About 93.1% had mucocutaneous manifestations, 5.2% gastrointestinal and mucocutaneous and 1.7% respiratory and mucocutaneous. In 20.7% of the cases, symptoms occurred during the first 24 hours. In three patients the OC was positive and the responsible drug was amoxicillin in two cases and ibuprofen in one. Conclusions: Allergy to drugs is rare in children but, considering its relevance in the management of infectious situations, it becomes important to refer all suspected cases to clarify the diagnosis.

Palabras clave : Allergy; drugs; oral challenge.

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