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Nascer e Crescer

versão impressa ISSN 0872-0754versão On-line ISSN 2183-9417

Resumo

MEIRELES, Daniel et al. Minimally invasive surfactant therapy in preterm infants: towards less invasive management. Nascer e Crescer [online]. 2021, vol.30, n.1, pp.18-25.  Epub 31-Jan-2021. ISSN 0872-0754.  https://doi.org/10.25753/birthgrowthmj.v30.i1.19182.

Introduction:

Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique.

Material and methods:

Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant.

Results:

Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (p=0.480), birth weight (p=0.299), fraction of inspired oxygen (FiO2) prior to surfactant (p=0.220), oxygen therapy duration (p=0.306), progression to intubation (p=0.712), or length of Neonatal Intensive Care Unit stay (p=0.778). FiO2 variation before and after surfactant administration was higher in MIST group (14% vs 9%, p=0.078). No significant complications were reported with either technique.

Conclusions:

MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO2 requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants.

Palavras-chave : INSURE; MIST; preterm; surfactant; ventilation.

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