Abstract

DIAS, Liliana  and  PEDROSA, Cláudia. Cross-allergy between penicillins and cephalosporins: a paradigm shift. Nascer e Crescer [online]. 2022, vol.31, n.1, pp.31-37.  Epub Mar 31, 2022. ISSN 0872-0754.  https://doi.org/10.25753/birthgrowthmj.v31.i1.20898.

Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy.

The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity.

Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.

Keywords : cephalosporin; cross-reactivity; penicillin; side chain.

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