Abstract

CASTRO, Raquel Vaz de; FAUSTINO, Joana; FERREIRA, Florbela  and  SAMPAIO, Lurdes. Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction. Nascer e Crescer [online]. 2023, vol.32, n.2, pp.103-107.  Epub June 30, 2023. ISSN 0872-0754.  https://doi.org/10.25753/birthgrowthmj.v32.i2.26186.

Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism.

The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction.

GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.

Keywords : acromegaly; gigantism; cause; clinical feature.

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