Abstract

SANTOS, H.A.; PEREIRA, C. M.  and  SILVA, F.. Ion Transfer Through DPPC Monolayers . Port. Electrochim. Acta [online]. 2005, vol.23, n.2, pp.263-274. ISSN 0872-1904.

The transfer of acetylcholine cation through a monolayer of a lipid, dipalmitoylphosphatidylcholine, formed at a polarized water | 1,2-dichloroethane interface has been studied using electrochemical impedance spectroscopy. The ion transfer process was characterized at different levels of interfacial coverage. From measurement of the cyclic voltammograms and double layer capacitance it was found that cation transfer through dipalmitoylphosphatidylcholine monolayers was cation and phospholipid concentration dependent. An increase on current intensity and capacitance values was observed at more positive potentials due to the transfer of acetylcholine across the interface in the absence or presence of lipid in the organic phase. The thermodynamic and kinetic parameters were also accessed from electrochemical impedance measurements.

Keywords : ion transfer; acetylcholine; monolayer; phospholipids; DPPC; impedance spectroscopy.

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