Abstract

KUMAR, K.G.; AUGUSTINE, P.  and  JOHN, S.. A Novel Potentiometric Sensor for the Determination of Nimesulide. Port. Electrochim. Acta [online]. 2007, vol.25, n.3, pp.375-381. ISSN 0872-1904.

A novel electrochemical sensor has been developed for the determination of nimesulide. The sensor is based on the NIM- molybdophosphoric acid (MPA) as the electroactive material in PVC matrix in presence of bis(2-ethyl hexyl) phthalate (BEP) as a plasticizer. The sensor showed a fast, stable, near Nernstian response for 1 ´ 10^-2 -1 ´ 10^-6 M NIM over the pH range 5 - 8 with a slope 55.6 ±0.5m V/decade and the response time is < 45 s. Selectivity coefficient data for some common ions show negligible interferences. The sensor was successfully applied for the determination of NIM in tablet and the results obtained are in good agreement with those obtained by the official method.

Keywords : Nimesulide; PVC membrane sensors; molybdophosphoric acid; potentiometric determination; pharmaceutical analysis.

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