Abstract

SINGH, Birjesh; MISHRA, Jyotsna  and  PRADHAN, Alka. Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex. Port. Electrochim. Acta [online]. 2015, vol.33, n.6, pp.323-330. ISSN 0872-1904.  https://doi.org/10.4152/pea.201506323.

Cobalt complex with flutamide was synthesized and physico-chemically characterized by amperometry, polarography, elemental analysis and IR spectrometry. After synthesizing the metal complex, it was evaluated for antibacterial and antifungal activities against various pathogenic microorganisms such as Streptococcus aureus, Prosteus mirabilis, Klebsiella pneumonia and Aspergillus niger, Nigrosporan sp Fungi. B16-F10 melanoma cell and C-57BL/6 mice have been used for anticancer screening of the metal complex for in vitro and in vivo study. The result of pharmacological studies with M:L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.

Keywords : Anticancer drug; Cobalt Complex; Polarography; Antibacterial activity; Pharmacology.

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