Abstract

ZAYED, Sayed I. M.; ORABY, Rasha G. A.; EL THOBETY, Ashwak E. A.  and  ABDEL-MOATY, Mona M.. Differential Pulse Anodic Voltammetric Determination of the Pharmaceutical Compound Pramipexole Dihydrochloride in its Tablets. Port. Electrochim. Acta [online]. 2017, vol.35, n.5, pp.305-312. ISSN 0872-1904.  https://doi.org/10.4152/pea.201705305.

The electrochemical behavior of pramipexole dihydrochloride was studied at carbon paste electrodes in 0.04 M Britton-Robinson buffer of pH 6.08, using cyclic and differential pulse voltammetric techniques. The oxidation of pramipexole dihydrochloride is an irreversible diffusion-controlled process. A differential pulse anodic voltammetric procedure has been developed for determination of the drug over the concentration range of 1.20 - 8.23 μg/mL, with detection and quantification limits of 0.21 and 0.68 μg/mL, respectively. The proposed method was successfully applied for the determination of the drug in its commercial tablets.

Keywords : pramipexole dihydrochloride; differential pulse anodic voltammetry; carbon paste electrode; pharmaceutical formulation.

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