Portugaliae Electrochimica Acta
ISSN 0872-1904
ZAYED, Sayed I. M.; ORABY, Rasha G. A.; EL THOBETY, Ashwak E. A. ABDEL-MOATY, Mona M.. Differential Pulse Anodic Voltammetric Determination of the Pharmaceutical Compound Pramipexole Dihydrochloride in its Tablets. []. , 35, 5, pp.305-312. ISSN 0872-1904. https://doi.org/10.4152/pea.201705305.
The electrochemical behavior of pramipexole dihydrochloride was studied at carbon paste electrodes in 0.04 M Britton-Robinson buffer of pH 6.08, using cyclic and differential pulse voltammetric techniques. The oxidation of pramipexole dihydrochloride is an irreversible diffusion-controlled process. A differential pulse anodic voltammetric procedure has been developed for determination of the drug over the concentration range of 1.20 - 8.23 μg/mL, with detection and quantification limits of 0.21 and 0.68 μg/mL, respectively. The proposed method was successfully applied for the determination of the drug in its commercial tablets.
: pramipexole dihydrochloride; differential pulse anodic voltammetry; carbon paste electrode; pharmaceutical formulation.