Abstract

ISSA, Yousry M.; KHALIL, Mohamed M.; ZAYED, Sayed I. M.  and  MUSTAFA, Naglaa. Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes. Port. Electrochim. Acta [online]. 2021, vol.39, n.5, pp.381-392.  Epub Oct 31, 2021. ISSN 0872-1904.  https://doi.org/10.4152/pea.2021390505.

Two carbon paste electrodes for oxymetazoline hydrochloride were constructed based on ion pair complexes of this drug, with sodium tetraphenylborate (NaTPB) or ammonium reineckate, using dibutyl phthalate and dioctyl phthalate as solvent mediators, respectively. The developed electrodes displayed a fast, stable response over the concentration range from 3.98x10-5 to 1x10-2 M oxymetazoline hydrochloride, with a near-nernstian slope of 59.0, 58.2 mV of concentration decade-1 and a limit of detection (LOD) of 3.31x10-5 and 3.72x10-5 M, in the oxymetazoline-tetraphenylborate and oxymetazoline-reineckate cases, respectively. The developed electrodes have been successfully applied for oxymetazoline hydrochloride determination in the Afrin nasal drop pharmaceutical formulation.

Keywords : Oxymetazoline hydrochloride; modified carbon paste electrode; potentiometry; pharmaceutical formulation.

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