Abstract

YASMEEN, Kousar et al. Copper and Lead Ions Cu(II) and (II) Anodic Stripping Voltammetry Quantitative Determination in Healthy and Cancerous Female Serum Samples. Port. Electrochim. Acta [online]. 2024, vol.42, n.1, pp.45-58.  Epub Feb 29, 2024. ISSN 0872-1904.  https://doi.org/10.4152/pea.2024420103.

Metals can contaminate the environment and increasingly affect ecological systems and public health worldwide. Cu(II) and Pb(II) ions play a significant part in increasing the cancer rate, since their amounts are higher in cancerous patients than in healthy individuals. Electrochemical methods have been extensively used for analyzing biological, beverages and food samples to estimate Cu(II) and Pb(II). The present study has employed LSASV for Cu(II) and Pb(II) determination in female patients (suffering from breast-cancer) cancerous blood serum samples. Optimized conditions for analysis have required: Gc, with an eacc of -0.2 V and a tacc of 400 s, as WE; 0.1 M AB (pH 5.1) as SE, at a stirring rate of 9 rpm and SR of 100 mV/s-1; Ag/AgCl as RE; and a Pt wire as CE. Under the optimized conditions, the cost-effective procedure was successfully applied for Cu(II) and Pb(II) determination in cancerous human serum. LOD was in the range of ppb. The analysis indicated higher Cu(II) and Pb(II) levels in cancerous female patients than in the healthy ones. Therefore, a strictly controlled diet is recommended.

Keywords : biological sample; Cu(II); healthy and cancerous serums; LSASV; Pb(II); public health.

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