Abstract

PEREIRA, Nídia et al. Diffuse Intestinal Involvement by Waldenström Macroglobulinemia: Clinical Case and Literature Review. Medicina Interna [online]. 2018, vol.25, n.2, pp.113-120. ISSN 0872-671X.  https://doi.org/10.24950/rspmi/CC/254/2/2018.

Gastrointestinal involvement in Waldenström macroglobulinemia is an extremely rare lymphoproliferative disorder. We describe a Waldenström macroglobulinemia patient presenting with diarrhea, dyspepsia, weight loss and malabsorption. Endoscopic studies revealed diffuse deposition of immunoglobulin M and kappa light chains in the mucosa of the small intestine. Later, on evaluation in the Haemato-Oncology clinic, the risk of death at 5 years was considered low, and thus no further therapeutic measures were proposed. The patient remained stable for three years, when she developed septic shock with rapidly progressive multiple organ failure and died a few hours after admission to hospital. The authors describe the case and elaborate a review of the literature on this pathology. We draw attention to this rare manifestation of an uncommon lymphoproliferative disorder to be considered in the differential diagnosis in a patient with a malabsorption syndrome.

Keywords : Immunoglobulin M; Intestinal Diseases; Malabsorption Syndromes; Waldenström Macroglobulinemia.

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