Abstract

BATISTA, Raquel; MARTINS, Sónia Cunha  and  PIMENTA, Maria de Fátima. Revisiting Drug-Induced Hyperthermia Syndromes. Medicina Interna [online]. 2018, vol.25, n.3, pp.224-232. ISSN 0872-671X.  https://doi.org/10.24950/rspmi/revisao/282/3/2018.

Fever is a frequent cause of recurrence in the Emergency Service but is not often associated with infection. Several drugs can condition the thermoregulation system causing a hypercatabolic state that can be fatal if not recognized in advance. There are five major drug-induced hyperthermic syndromes: (1) malignant neuroleptic syndrome, (2) serotonergic syndrome, (3) anticholinergic syndrome, (4) sympathomimetic syndrome and (5) malignant hyperthermia syndrome. The authors aim to review these hyperthermic drug-induced syndromes, their differential diagnosis, possible treatments, as well as the deleterious effects of sustained hyperthermia, evidencing their neurological consequences. Drug-induced hyperthermia is a diagnosis often overlooked when approaching febrile illnesses and whose treatment includes discontinuation of the responsible drug, supportive measures and in some cases adequate pharmacological therapy

Keywords : Fever/chemically induced; Hyperthermia; Pharmaceutical Preparations.

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