Abstract

PINHO, Mónica et al. Seven Years of Febrile Neutropenia in Internal Medicine Department. Medicina Interna [online]. 2019, vol.26, n.2, pp.97-106. ISSN 0872-671X.  https://doi.org/10.24950/rspmi/O/241/18/2/2019.

Introduction: Febrile neutropenia remains a serious side effect of chemotherapy and is a major cause of morbidity and mortality, as well as healthcare resource, and may compromise the efficacy of antineoplastic treatments by delaying and dose reductions of chemotherapy. The data about oncological inpatients with febrile neutropenia is scarce on literature, so this study pretends to characterize this population in a period of seven years at an internal medicine department and knowing more about this medical approach. Results: 156 inpatients were included in a total of 187 hospitalizations by febrile neutropenia. More than 50% was man, with a median age of 67 years old and 63.0% had advanced oncological disease. Fewer was present in 85.6% of admissions and 39.0% had severe neutropenia. Blood cultures were collected in 77.9% of episodes and 20.0% had bacteraemia. Gram-negative agents were the most frequent and the antibiotic association had a downward trend, being the carbapenems the most used. Mortality rate was about 17.0%, of which 62.5% had severe neutropenia and 75.0% stage IV. Conclusion: The creation of protocols and their auditing make it possible to evaluate the clinical work performed on the service and to improve the health care provided

Keywords : Anti-Bacterial Agents; Antineoplastic Agents/ adverse effects; beta-Lactams; Chemotherapy-Induced Febrile Neutropenia: Febrile Neutropenia/ chemically induced; Granulocyte Colony-Stimulating Factor; Hospitalization.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )