Resumo

SILVA, Cláudio Nunes; CEIA, Filipa  e  TAVARES, Margarida. SARS-CoV-2 Immune Response: An Overview. Medicina Interna [online]. 2020, vol.27, suppl.1, pp.97-104. ISSN 0872-671X.  https://doi.org/10.24950/rspmi/COVID19/CHUSJ/S/2020.

Despite all that is recognized so far on the ongoing SARS-CoV-2 pandemic, many questions remain to be answered, particularly in what concerns pathogen interaction with the human host and whether or not the acquired immune response is protective against reinfection in the long-term. The spectrum of COVID-19 ranges from asymptomatic infections to progressive critical states, a direct upshot from the complex interplay between virus pathogenicity and host antiviral defense. This review focuses on the immunologic response and disarrangements underlying the SARS-CoV-2 pathophysiology, gathering the information not only from the lessons learnt from SARS and MERS-CoV epidemics but also from what is already known about SARS-CoV-2 to date. This knowledge is paramount from the standpoint of disease prevention and control as well as diagnostic pipeline and treatment.

Palavras-chave : Antibodies Neutralizing; Betacoronavirus; Coronavirus Infections/immunology; COVID-19; Immunity Cellular; Pandemics; Betacoronavirus; Immunology; Cell-medianted Immunity; Humoral Immune Response; Innate Immunity; Neutralizing Antibodies.

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