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Medicina Interna
Print version ISSN 0872-671X
Abstract
ALVES, Sara Carneiro; SANTOS, José Augusto; RODRIGUES, Catarina Ramos and MOURA, Adriana. Evidence of Renin-Angiotensin System Modifiers in the Prevention of Episodic Migraine. Medicina Interna [online]. 2021, vol.28, n.1, pp.52-58. Epub Mar 15, 2021. ISSN 0872-671X. https://doi.org/10.24950/r/190/20/1/2021.
:
Migraine is a common and disabling disease. Experimental models suggest an association between renin-angiotensin system and migraine development. This paper aims to review the evidence of angiotensin inhibitors in reducing migraine episodes.
Methods:
We searched for guidelines, systematic reviews, meta-analysis and randomized controlled trials. Level of evidence and strength of recommendation (SOR) attribution were based on Strength of Recommendation Taxonomy (SORT).
Results:
We identified 63 articles, from which we selected eight: four guidelines, two meta-analysis and two systematic review.
Discussion/Conclusion:
Candesartan 16 mg/day may be used as a preventive treatment of episodic migraine (SOR B), in spite of not being recommended as the first line of treatment. Lisinopril also showed some potential. (SOR B)
Keywords : Angiotensin-Converting Enzyme Inhibitors; Migraine Disorders/prevention & control.
