Abstract

MARTINS, Cristiana Honrado et al. Síndrome Hemolítica Urémica e Infeção por SARS-CoV-2: Uma Associação Rara. Medicina Interna [online]. 2023, vol.30, n.3, pp.46-48.  Epub Oct 25, 2023. ISSN 0872-671X.  https://doi.org/10.24950/rspmi.1616.

Thrombotic microangiopathies (TMA) are rare diseases, with high morbimortality. Among them, atypical hemolytic ure-mic syndrome (HUS), associated with deregulation of alternative complement pathway (genetic/acquired), represents a diagnostic challenge. Characterized by thrombotic microangiopathy, acute renal failure is one of its main features. Etiological/precipitant detection (TMA triggers) is essential, even though about 30% of cases remain idiopathic. There is not a direct diagnostic test, which makes this an exclusion final diagnosis (after primary and secondary causes are ruled-out). Further testing for genetic variations is important for prognostic purposes. We describe the case of a 40 years old woman, whose final diagnostic was an atypical HUS associated with SARS-CoV-2 infection. This case stands out by its rarity.

We underline the importance of prompt initial diagnosis and timely target treatment beginning: Eculizumab, the only one available in Portugal at the moment. Plasmapheresis and/or renal replacement therapy must be considered case by case.

Keywords : COVID-10/complicações; SARS-CoV-2; Síndrome Hemolítica Urémica Atípica/diagnóstico; Síndrome Hemolítica Urémica Atípica/tratamento..

        · abstract in Portuguese     · text in English     · English ( pdf )