Abstract

SOUSA, H. T. et al. Adalimumab: uma nova opção na doença de crohn?. J Port Gastrenterol. [online]. 2006, vol.13, n.5, pp.229-232. ISSN 0872-8178.

Fifteen-year-old female with non stenotic and non fistulizing Crohn's colitis for one year. We report a steroid dependent and refractory to azathioprine patient, in whom disease remission was obtained with infliximab, which sought to be discontinued after severe acute reaction to third infusion. Treatment with steroids and methotrexate was established, but effective control of the disease was not achieved. We then obtained permission for the use of adalimumab, which allowed methotrexate reduction, steroid postponement and complete disease remission. This case illustrates the recently presented promising results regarding the use of adalimumab on Crohn's disease, and on the particular setting of patients with intolerance or loss of response to infliximab. We briefly review the existing literature on this probable new therapeutic option for the treatment of Crohn's disease.

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