Abstract

MARQUES, N. et al. Caracterização da Resposta Virológica Sustentada na Terapêutica da Hepatite C Crónica pela Avaliação à 4ª Semana . J Port Gastrenterol. [online]. 2007, vol.14, n.5, pp.228-232. ISSN 0872-8178.

Introduction: Recent studies suggest that negative HCV-RNA at week 4 of HCV treatment, known as rapid virological response has a high positive predictive value of sustained virological response (SVR). Aim: To describe a group of patients who achieved undetectable levels of HCV-RNA after 4 weeks of HCV treatment. Methods: Retrospective study of patient’s clinical records of patients who have completed HCV treatment during a 2 years period (2004-2005). Results: 42 patients were included, 10 of them co-infected by HIV. The majority of patients had HCV genotype 1 (52,4%), low HCV viral load [≤800 000 IU/ml] (92,9%) and elevated ALT. SVR was 85,7%. Conclusions: Nowadays, an individualization of chronic hepatitis C treatment is required in order to allow those unlikely to achieve a SVR to be spared the expense and potential toxicities of continued therapy.

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