Abstract

LEITE, S. et al. CT colonography for colorectal lesions: prospective trial. J Port Gastrenterol. [online]. 2009, vol.16, n.6, pp.230-239. ISSN 0872-8178.

BACKGROUND: CT colonography (CTC) has a controversial diagnostic role in the diagnosis of colorectal lesions. aims: In this study we prospectively assess the accuracy and patient experience with CTC compared with optical colonoscopy (OC) in a evaluator-blinded study of 100 patients referred for colonoscopy who previously performed CTC. results: Six patients were excluded due to impossibility to perform CTC or OC. Sensitivity (S) and specificity (E) of CTC for detecting polyps ≥10 mm was 57% (95% confidence interval [IC], 12-86%) and 96% (95%CI, 43-63%); overall polyps S = 49% (95%CI, 12-86%) and E = 67% (95%CI; 57-77%); between 6-9 mm S = 31% (95%CI, 6-56%) and E = 80% (IC95%, 71-89%); ≤ 5 mm S = 18% (95%CI, 7-31%) and E = 88% (95%CI, 71-89%). CTC missed 3 flat lesions and 1of the 2 cancers detected on OC. 56% patients expressed preference for CTC. Conclusions: In this study, overall estimated sensitivity of CTC was inadequate to detect polyps for polyps, although it was better in the detection of polyps with significant dimensions. Estimated specificity of CTC was high for polyps. CTC had a relevant number of missed flat lesion and cancer. Patients preferred CTC over OC.

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