Abstract

SANTOS, Hermano et al. Helicobacter pylori prevalence and genetic characterization in a group of dyspeptic patients from Algarve. J Port Gastrenterol. [online]. 2010, vol.17, n.3, pp.102-107. ISSN 0872-8178.

INTRODUCTION: The role of Helicobacter pylori (Hp) in the ethiology of several gastroduodenal diseases is well established; it is thus important to know its prevalence and characteristics in different geographical zones. AIMS: to evaluate the prevalence of Hp infection in a dyspeptic population, to identify its genetic characteristics and correlate them with endoscopic findings. METHODS: 205 dyspeptic patients submitted to endoscopy were included. Helicobacter pylori presence was evaluated by rapid urease test as well as bacteriology tests and histopathology; infection was admitted when at least two tests were positive. We used PCR to characterize the genes cagA, vacA, oipA and babA in 22 of the isolated strains. Statistical: χ2 and exact Fisher’s tests; CI - 95%. RESULTS: prevalence: 44,9% (higher between 30 and 59 years old); genes cagA + in 90,9%, oipA functional in 78,9%, babA + in 50% and genotype s1m1 in 31,8% of the strains. Infection was only associated with duodenal ulcer. CONCLUSIONS: 1) Prevalence of the infection: 44,9 %, decreasing after 60 years of age. 2) Association of the infection only with duodenal ulcer. 3) rate of cag A + and oipA ON strains higher than expected in a western country.

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